Associated with destruction of cartilage. However, the AIA has been more used in the evaluation of pharmaceutical agents and therefore, there is more data for comparison with man. Numerous agents used in the clinic show activity in this model, such as: corticosteroids, indomethacin and to a lesser extent methotrexate Flekosteel.
Arthritis induced by type II collagen in mouse is considered another acceptable model for this disease, in which polyarthritis usually not symmetrical develops and the lesions in the affected joints are similar to those seen in collagen arthritis in rats. This model is useful for evaluating the effects of biological agents.
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